Connectome Update (BSP 103)

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Olaf Sporns, PhD

Olaf Sporns, PhD

The Human Connectome is a description of the structural connectivity of the human brain, but according to Olaf Sporns, author of Discovering the Human Connectome, this description  must include a description of the brain's dynamic behavior. I first talked with Sporns back in BSP 74, but BSP 103 gave us a chance to talk about recent progress in connectomics.

Sporns sees the study of the brain's connections as fundamental to understanding how the brain works.

"It will allow us to ask new questions that perhaps we couldn’t ask before. It will be a foundational data set for us, just like the genome is. We will not be able to imagine neuroscience going back to a time when we did not have the connectome, but it will not give us all the answers.”

In his first book, Networks of the Brain, Sporns described how Network Theory provides important tools for dealing with the large data sets that are created by studying complex systems like the human brain.  In BSP 103 we discuss both the challenges and the promise of Discovering the Human Connectome. 

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Synapse Evolution with Seth Grant (BSP 101)

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Seth Grant (click photo to hear interview)

Seth Grant (click photo to hear interview)

Early in his career Seth Grant helped develop the transgenic mice that Eric Kandel used in his studies of how memory works. Since then he has combined his skill in genetics with his work on isolating the proteins that form the functional components of the synapse. (The synapse is a key component in the nervous systems of all multi-cellular animals.) When we last talked back in BSP 51 I was particularly struck by how many of these proteins actually evolved with single celled life--long before the arrival of nervous systems.

Recently Grant's work has focused on the discovery that the vertebrate synapse is actually much more complex than the one present in invertebrates. For BSP 101 we got together to talk about two papers he and his collegues recently published in Nature Neuroscience. These papers explore how small changes in the synapse proteins effect learning in measurable ways.

Grant has a special gift for making complex ideas clear, which means that this interview can be enjoyed by all listeners, even those who are new to the Brain Science Podcast and neuroscience. 

How to get this episode:

  • Premium mp3 [Buy for $2]

  • Buy Transcript for $2.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE. The 50 most recent episodes are also free. Just subscribe in your favorite podcasting app.

References: 

  • S.G.N. Grant, T. J. O'Dell, K. A. Karl, P. L. Stein, P. Soriano, and E. R. Kandel, "Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice." Science 258 (1992):1903-10.

  • Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG, "Evolutionary expansion and anatomical specialization of synapse proteome complexity." Nature Neuroscience 11 (2008) 799-806.

  • Nithianantharajah, J., Komiyama, N., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J. & Grant, S. G. N. “Synaptic scaffold evolution generated components of vertebrate cognitive complexity.” Nature Neuroscience 16 (2013) 16-24. doi:10.1038/nn.3276

  • Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., O'Dell, T. J., Grant, S. G. N. & Komiyama, N. “Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior.” Nature Neuroscience 16 (2013) 25-32. doi:10.1038/nn.3277

  • List of research papers by Seth Grant

  • See FREE transcript for more links and references

  • More episodes about brain evolution: BSP 47, BSP 48, and BSP 51

Announcements: 

Leave feedback here or visit the Brain Science Podcast discussion group at Goodreads.com, our Fan Page on Facebook or our page on Google+.

Brain Fitness with Alvaro Fernandez (BSP 100)

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Alvaro Fernandez of SharpBrains

Alvaro Fernandez of SharpBrains

I have been using the SharpBrains website as a source of information and ideas since the early days of my Brain Science Podcast, so it seemed fitting to invite SharpBrains co-founder Alvaro Fernandez to be my guest for Episode 100.   We talked about the second edition of The SharpBrains Guide to Brain Fitness: How to Optimize Brain Health and Performance at Any Age, which he co-authored with Dr. Elkhonon Goldberg (BSP 18). The goal of this book is to give people from all backgrounds a practical guide for evaluating the current science and establishing their own "brain fitness" regimen, much in the way that each of us must choose a physical fitness that meets our individual needs and lifestyle.

Brain Fitness should not just be a concern for older people, it should become a key component of a healthy lifestyle at any age. The SharpBrains Guide to Brain Fitness is a great first step.

How to get this episode:

  • Buy Episode mp3 for $2

  • Buy Transcript for $2.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE. All episodes posted after January 1, 2013, are free. See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Links and References: 

Celebrating BSP 100

To celebrate Episode 100 of the Brain Science Podcast I invited listeners to contribute audio to the show. I couldn't use everything, but I want to thank everyone who submitted content.  The following listeners are featured:  

  • "I Got a Brain" Written and Performed by Dr. Jay Einhorn

  • Interview with Darryl Ferges

  • "Mindfire" (new theme music) by Tony Cotraccia

  • Audio comments: Leon Mcgahee, MD., Eric Lindley, Julio Dantos, Hamish Kebb, and Adelia Moore, PhD

  • Email from Jana Johnson

Send Feedback to brainsciencepodcast@gmail.com

Interview: Temple Grandin (BSP 99)

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photo by Rosalie Winward

photo by Rosalie Winward

Last month I posted a detailed discussion of Temple Grandin's latest book The Autistic Brain: Thinking Across the Spectrum (with Richard Panek), so I am pleased to share a follow interview with Dr. Grandin (BSP 99). This interview is different from the typical Brain Science Podcast because our focus is on the practical issues that face people who are dealing with autism. Of course, as Dr. Grandin emphasized, autism occurs across a wide spectrum ranging from those who can never learn to speak to high functioning professionals exemplified by Temple Grandin herself.  Dr. Grandin speaks from personal experience grounded in her own scientific curiosity.

How to get this episode:

Links and References:

Announcements: 

  • The Brain Science Podcast mobile app is now available for Windows 8 devices.

  • Deadline for listener submissions for BSP 100 is August 1, 2013

  • Unfortunately Mensana has closed down, so CEU's are not currently available for the Brain Science Podcast. I am looking for a new vendor.

  • Don't forget to sign up for the BSP Newsletter so that you can get episode show notes automatically, and never miss a new episode.

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"The Autistic Brain" by Temple Grandin (BSP 98)

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 The Autistic Brain: Thinking Across the Spectrum  by Temple Grandin (with Richard Panek), is a tremendous gift, not just to patients and their families, but also to teachers, mentors, friends, and everyone who is interested in understanding how our brains make us who we are.

I think that this is a book everyone should read because as we come to appreciate the fact that the strengths and challenges of autism occur across a broad spectrum, we may also realize that some of these issues actually affect people who aren't considered autistic.  It is not the label that matters.  What does matter is recognizing that each of us has his or her own strengths and weaknesses, but thanks to brain plasticity, we all have the potential to nurture our strengths and, when necessary, accommodate our weaknesses.

 

How to get this episode:

  • Buy Transcript for $1.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE. All episodes posted after January 1, 2013, are free. See the individual show notes for links the audio files.

References and Related Episodes:

Announcements: 

  • I am still trying to schedule an interview with Dr. Temple Grandin, but there is a possibility that the next episode of the Brain Science Podcast will not come out until August 2013.

  • The Deadline for listener submissions to Episode 100 is August 1, 2013.

  • Several products are not available directly on this website including the PDF version of Are You Sure? The Unconscious Origins of Certainty by Ginger Campbell, MD and a zip file contain BSP 1-10. Click here to learn more.

  • Be sure to sign up for the Brain Science Podcast Newsletter so that you can receive show notes automatically and NEVER miss a new episode. (But there was a glitch last month, so if you did not get the show notes for BSP 97, please click here.

Neuroanthropolgy: What Is It and WHY Should You Care? (BSP 97)

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The-Encultured-Brain1.jpg

You may be tired of seeing the prefix "neuro" used to describe every new fad, but The Encultured Brain: An Introduction to Neuroanthropology [2012] edited by Daniel H. Lende and Greg Downey makes an impassioned argument for why neuroscience and anthropology should be working together to unravel the ongoing mystery of how our brains make us who we are.  The latest Brain Science Podcast  (BSP 97) is a thought-provoking conversation with Downey and Lende.  After explaining that anthropology can offer neuroscience field data about "brains in the wild," we explore two case studies that demonstrate the promise of this new partnership.

How to get this episode:

Subscribe to the Brain Science Podcast or listen on the BSP Mobile app.

References and Links:

Announcements:

  • he Brain Science Podcast is nearing episode 100! I want to include listener comments. Send your emails and mp3 files to brainsciencepodcast@gmail.com or click here to learn more.

  • The Brain Science Podcast Newsletter has moved to Mailchimp. Click here for the new sign-up form.

  • Please nominate the Brain Science Podcast as one of the best science podcasts on the web at http://www.thesciencestudio.org.

  • Keep an eye out for the latest BSP News!

Robert Burton's "Skeptic's Guide to the Mind" (BSP 96)

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​Robert Burton, MD

​Robert Burton, MD

In On Being Certain: Believing You Are Right Even When You're Not, Robert Burton showed that the feeling of certainty, which is something we all experience, has its origin in brain processes that are both unconscious and inaccessible to consciousness . Now in his new book, A Skeptic's Guide to the Mind: What Neuroscience Can and Cannot Tell Us About Ourselves, he extends these ideas to other mental sensations such as our feeling of agency and our sense of causation.  The idea that much of what our brain does is not accessible to our conscious awareness is NOT new, but Dr. Burton considers the implications for our understanding of the MIND.

When we talked recently (BSP 96), Dr. Burton explained that his new book has two main parts.  In the early chapters, he extends the principles he developed in On Being Certain to other mental sensations. We tend to take things like our feeling of certainty, agency, and causation for granted, but he points out that these are generated in parts of the brain that we can neither access or control.  What makes A Skeptic's Guide to the Mind stand out is that Burton then explores the implications of this reality. He argues that while we can become ever more knowledgeable about how our brain works, the MIND, which is something that we each experience subjectively, is much more elusive.

The fact that we are trying to study the MIND with the MIND has inherent limitations and I think that Dr. Burton is right when he says our response should be HUMILITY.

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Related Episodes:

  • BSP 42: A discussion of On Being Certain

  • BSP 43: Interview with Robert Burton about On Being Certain

  • BSP 67: Interview with Thomas Metzinger, author of The Ego Tunnel

  • BSP 85: Interview with Sebastian Seung, author of Connectome.

Send me feedback at brainsciencepodcast@gmail.com.

Understanding Pain (BSP 95)

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UnderstandingPain-Cevero-140.jpg

In Understanding Pain: Exploring the Perception of Pain,  Dr. Fernando Cervero does a wonderful job of condensing his 40+ years of research and immersion in the field of pain research into a concise but readable account.  It's a great introduction, and it's bound to inspire a new generation of physicians and researchers.

I interviewed Dr. Cervero in BSP 93, and this month's podcast (BSP 95) is the promised second part of our discussion of pain.  I focus on some of the topics that Dr. Cervero and I did not have time to discuss, including a look at how the mechanisms of acute pain differ significantly from those of chronic pain.  The growing appreciation of these differences offers hope to the millions of people around the world who suffer from chronic pain, but the ongoing efforts of researchers like Dr. Cervero also offer hope of improved pain relief for everyone.

Unfortunately, for those of you who love audiobooks, Understanding Pain, is not available in audio; but it is a relatively short book (under 200 pages) that I recommend to everyone.  

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References and Links:

Announcements: