Neuropsychology and the Study of Memory - Dr. Brenda Milner (BS 129)

Neuropsychology and the Study of Memory - Dr. Brenda Milner (BS 129)

BS 129 features pioneering neuroscientist Brenda Milner. Dr. Milner is best known for work work on memory including key discoveries she made while working with the famous patient HM. She also made important discoveries about the differences between the brain's hemispheres by studying the so-called "split brain" patients. This interview was recorded in 2008 when Dr. Milner was 90, but I am glad to report that she is still going strong at age 98.

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Placebo Research Update with Fabrizio Benedetti (BSP 127)

Placebo Research Update with Fabrizio Benedetti (BSP 127)

BSP 127 marks the return of placebo researcher Fabrizio Benedetti, author of Placebo Effects: Understanding the mechanisms in health and disease. We talk about some of Dr. Benedetti's most recent research into placebo effects in pain relief and in high altitude headaches. We also talk about some of the ethical issues about using placebos.

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9th Annual Review of Neuroscience (BSP 125)

9th Annual Review of Neuroscience (BSP 125)

BSP 125 is our ninth annual review episode. We review some key ideas from each of the 10 episodes that were released in 2015, and then take a look ahead to 2016. Check out the show notes for a complete lists of this year's guests and the books we covered. The transcript for this episode is FREE.

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Phenomenology and Embodied Cognition (BSP 123)

Phenomenology and Embodied Cognition (BSP 123)

BSP 123 is an interview with philosopher Anthony Chemero, author of Radical Embodied Cognitive Science and Phenomenology: An Introduction with Stephan Käufer. The focus of this interview is understanding how phenomenology has influenced psychology and cognitive science.

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"How Do you Feel?" with Dr. Bud Craig (BSP 121)

"How Do you Feel?" with Dr. Bud Craig (BSP 121)

BSP 121 is an interview with AD (Bud) Craig, author of How Do You Feel?: An Interoceptive Moment with Your Neurobiological Self. Even though his book is quite technical he does a great job of describing his discoveries in a way that is accessible for listeners of all backgrounds.

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More on CI Therapy with Ed Taub (BSP 120)

More on CI Therapy with Ed Taub (BSP 120)

BSP 120 is the second half of our interview with Dr. Edward Taub who leads the ongoing development of Constraint Induced (CI) Therapy. We continue to explore the role of learned non-use as well as the expansion of CI Therapy beyond stroke to include traumatic brain injury (TBI) and even spinal cord injuries.

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Dr. Ed Taub revolutionizes Stroke Rehab (BSP 119)

Dr. Ed Taub revolutionizes Stroke Rehab (BSP 119)

BSP 119 is the first half of a new interview with Dr. Edward Taub, inventor of Constraint Induced Movement Therapy, which is a revolutionary approach to rehabilitating people with brain injuries, such as stroke and trauma.

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BSP 115: Eastern Philosophy and Western Neuroscience

EvanThompson

Evan Thompson (click photo to buy BS 115 audio)

Scientific interest in the Mind and Consciousness is relatively new, but both Western and Eastern Philosophy have a long tradition of exploring these topics. In his new book Waking, Dreaming, Being: Self and Consciousness in Neuroscience, Meditation, and Philosophy, Evan Thompson explores how these diverse traditions can inform and enrich one another.

Thompson goes beyond a narrow view of consciousness, which focuses only on the waking state. Instead he considers how dreaming, lucid dreaming, and even near death experiences can advance our understanding of how our brain's generate both consciousness and our sense of Self. 

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Related Episodes:

  • BSP 5: Very brief introduction to Philosophy of Mind.

  • BSP 55: Patricia Churchland, PhD, discusses Neurophilosophy.

  • BSP 58: Alva Noë, PhD, discusses Out of Our Heads: Why You Are Not Your Brain, and Other Lessons from the Biology of Consciousness.

  • BSP 67: Thomas Metzinger discusses The Ego Tunnel: The Science of the Mind and the Myth of the Self.

  • BSP 73: Embodied Cognition with Lawrence Shapiro, PhD.

  • BSP 81: Patricia Churchland discusses Braintrust: What Neuroscience Tells Us about Morality.

  • BSP 89: Evan Thompson discusses Mind in Life: Biology, Phenomenology, and the Sciences of Mind.

  • BSP 96: Robert Burton, MD discusses A Skeptic's Guide to the Mind: What Neuroscience Can and Cannot Tell Us About Ourselves.

Announcements:

  • This month's Audible recommendation: The Teenage Brain: A Neuroscientist's Survival Guide to Raising Adolescents and Young Adults byFrances E. Jensen, MD

  • The next episode of the Brain Science Podcast will feature Dr. Norman Doidge talking about his new book The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity.

  • Reminder: the 25 most recent episodes of the Brain Science Podcast are always free, but Premium subscribers have unlimited access to all back episodes and transcripts. The Brain Science Podcast Mobile App is FREE. It is a great way to consume both free and premium content (since this will not appear in iTunes or other podcasting apps).

  • Please share your feedback about this episode by sending email to brainsciencepodcast@gmail.com or going to the Brain Science Podcast Discussion Forum at http://brainscienceforum.com. You can also post to our fan pages on Facebook or Google+. I am looking for help with these community pages so please email me at brainsciencepodcast@gmail.com if you are interested.

Exercise Promotes Brain Plasticity (BSP 111)

John Ratey, MD Click picture to hear interview

John Ratey, MD
Click picture to hear interview

According to psychiatrist Dr. John Ratey the best way to improve brain plasticity is by exercise.  I spoke to him shortly after he published his best-seller Spark: The Revolutionary New Science of Exercise and the Brain (2008). He commented that even compared to drugs "Exercise is the champ."

Download BSP 111

Since then Dr. Ratey has been traveling the world promoting the value of exercise for people of all ages, but his main focus has been on young people and on trying to restore and invigorate physical education programs in the schools. In Spark he provided some of the preliminary evidence that vigorous exercise promotes better academic performance, but that evidence had continued to mount.

Besides improving academic performance regular exercise also helps over all mental health. Exercise is especially effective for problems like depression and ADHD. Our brains rely on a complex mixture of neuroactive chemicals (neurotransmitters, etc.), but since our understanding of these is still very primitive, treatment with drugs can be unpredictable. Dr. Ratey feels that medications can be an important part of treating problems like ADHD, but that exercise should be included as an essential element.

Of course, even those of us who don't struggle with mental illnes are concerned with keeping our brains healthy as we age. Here again Dr. Ratey argues that exercise is essential. He speculates that exercise tricks your brain "into thinking that you're younger and that you still need to grow, as opposed to being stationary and having atrophy occur." Also, when you keep on learning (new things) your brain continues to respond and build new pathways. This is very similar to what Dr. Michael Merzenich (one of the pioneers of brain plasticity) told us in BSP 105.

Dr. Ratey is working on a new book that will be an update on the science that has been done since Spark was published, but his 2008 interview remains one of my favorites. That's why I just released an updated version of this interview as BSP 111. 

How to get this episode:

  • FREE: audio mp3 (click to stream, right click to download)

  • Buy Episode Transcript for $1.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE. All episodes posted after January 1, 2013, are free. See the individual show notes for links the audio files.

References and Links

Related Episodes:

Announcements:

  • Reminder: The Brain Science Podcast mobile app is now FREE for iOS, Android and Windows Mobile. Click here to learn more.

  • This is the first time I have reposted an older episode. I need listener suggestions about what other older episodes you would like me to share with new listeners.

  • Don't forget to check out my other podcast Books and Ideas.

  • Please share your feedback about this episode by sending email to brainsciencepodcast@gmail.com or going to the Brain Science Podcast Discussion Forum at http://brainscienceforum.com. You can also post to our fan pages on Facebook or Google+.

"Neurobiology for Dummies" (BSP 110)

Frank Amthor, PhD

Frank Amthor, PhD

Frank Amthor's latest book Neurobiology for Dummies isn't just for readers who are new to neuroscience. In this excellent follow-up to his Neuroscience for Dummies Dr. Amthor discusses a wide variety of brain-related topics. Since I have known Frank for several years it was a special treat to interview him for BSP 110. We talked about a wide variety of ideas ranging from what makes neurons special to how brains differ from current computers. 

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Consciousness as Social Perception (BSP 108)

Michal Graziano and Kevin

Michal Graziano and Kevin

In his latest book Consciousness and the Social Brain  Princeton neuroscientist Michael Graziano proposes a unique and compelling theory of consciousness. He proposes that the same circuits that the human brain uses to attribute awareness to others are used to model self-awareness. He emphasizes that his attention schema theory is only tentative, but it is testable and it does fit our current knowledge of brain function.

In a recent interview for the Brain Science Podcast (BSP 108), Graziano used the following clinical example to clarify his approach. A colleague had a patient who was convinced that he had a squirrel in his head. When confronted with the illogic of his claim the patient replied “Not everything can be explained by science.” In this example it is clear that the squirrel doesn’t really exist, so the question to be answered is HOW did his brain reach the conclusion that it does.

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While imagining one has a squirrel in one’s head is thankfully rare, we also know that our subjective experiences of the world are not necessarily accurate. Our perception of the world is shaped by how our brain processes the sensory inputs it receives. For example, we perceive white light as an absence of color even though in reality it consists of all wavelengths.

Perception is something our brains do constantly and which we can not consciously control. In considering awareness (and by extension consciousness) perception-like Graziano is emphasizing several important features. The most important is probably the fact that it is only “quick and dirty model” of what is really going on, which means that our intuitions about consciousness are not necessarily reliable. In fact, humans have a strong tendency to over-attribute awareness to the world around us. This is part of the social circuitry that has made us the most successful species in the earth’s history, but it can also lead to amusing results (as anyone who has interacted with Siri on an iPhone has no doubt observed).

Another implication of considering awareness as a form of social perception is that it reverses the usual approach taken to understanding consciousness. Instead of asking how a physical brain can produce something subjective and non-physical called consciousness, we ask what kind of information processing leads to the conclusion that I (or anyone else) is conscious. As Graziano points out, this is a “mechanistic” model. Not only can it be tested but it has interesting implications. Dr. Graziano concluded that one of the key implications is "that awareness and consciousness are tools for information processing, and they are mechanistically understandable, and presumably can be engineered.”

I find the attention schema theory to be very compelling. Besides being testable, it has a simple elegance that I appreciate. It also explains why most humans experience a world filled with spirits, and are utterly convinced that their own consciousness is something special and non-physical.

Related Episodes:

Since understanding consciousness is one of the deepest questions facing neuroscience, it has been explored on many previous episodes of the Brain Science Podcast. Rather than list all those episodes I want to mention just a few that I think are particularly relevant to this month’s episode. 

Announcements:

Sleep Science with Penny Lewis (BSP 107)

Penny Lewis

Penny Lewis

In The Secret World of Sleep: The Surprising Science of the Mind at Rest Dr. Penelope A. Lewis provides a highly readable account of the fascinating world of sleep research. Fascinating research is being carried out with animals as varied as fruit flies and rats, as well as with humans. I was surprised to learn that most people actually find it fairly easy to fall asleep in an fMRI scanner.

I have just posted an interview with Dr. Lewis (BSP 107) that includes a discussion of the role of sleep in memory as well as interesting findings about how synapses in the brain actually change during sleep. We still don't know exactly what sleep (and dreaming) are essential, but research in this field is growing. Dr. Lewis is excited about emerging research that suggests improving slow wave sleep may significantly improve learning and memory.

How to get this episode:

  • Buy Audio MP3 for $2.

  • Buy Episode Transcript for $1.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE. All episodes posted after January 1, 2013, are free. See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Announcements:

  • Dr. Campbell has been invited to speak at The Amazing Meeting 2014, which will be held in Las Vegas July 10-13. This year's theme is Skepticism and The Brain. Stay tuned to learn more.

  • It will soon be possible to gain CE credit for selected episodes of the Brain Science Podcast.

  • Listener John Richards has relaunched is excellent Neuroscience Glossary at http://richardsonthebrain.com. This is a great place to learn more about terms and ideas that you hear on the Brain Science Podcast.

  • Please post your comments about this episode in our Goodreads Group at http://brainscienceforum.com or send email to brainsciencepodcast@gmail.com.

"The Cognitive-Emotional Brain" (BSP 106)

Luiz Pessoa of the University of Maryland

Luiz Pessoa of the University of Maryland

In The Cognitive-Emotional Brain: From Interactions to Integration neuroscientist Luiz Pessoa argues that emotion and cognition are deeply intertwined throughout many levels of the brain. In a recent interview (BSP 106) Pessoa and I focused on recent discoveries about the amygdala and Thalamus that challenge traditional assumptions about what these structures do. The amygdala processes more than fear (and other negative stimuli) and the Thalamus is more than  a mere relay station.

This a fairly technical discussion but Pessoa did a good job of making the material accessible to all listeners. The reason I think these concepts matter is that not only do they challenge overly simplistic notions of how the brain works, but they also challenge our tendency to see emotion and cognition as separate and often opposing processes.

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References and Additional Reading

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Brain Plasticity with Michael Merzenich (BSP 105)

Michael Merzenich

Michael Merzenich

If you have read anything about brain plasticity you have seen the name Michael Merzenich. Dr. Merzenich is one of the pioneers in this field, having spent over 30 years documenting that the human brain (and that of other mammals) continues to change throughout life. I interviewed Dr. Merzenich several years ago (BSP 54), but the publication of his first book Soft-Wired: How the New Science of Brain Plasticity Can Change Your Life gave us another opportunity to talk about how we can apply these discoveries in our daily lives.

According to Dr. Merzenich, "No matter how much you've struggled, no matter where you've been in your life, you're in charge of your life going forward.  And you have the capacity; you have the resources to change things for the better—always have that capacity.  And that's what the book is trying to emphasize. “ (BSP 105)

I found Soft-wired very compelling because it combines a clear explanation of the science with many stories about real people facing a wide variety of cognitive challenges. The overall tone of the book is very optimistic even though it also considers the way bad choices can contribute to cognitive decline. 

How to get this episode:

Related Episodes:

  • BSP 10: Introduction to Brain Plasticity.

  • BSP 17: Discussion of The Wisdom Paradox: How Your Mind Can Grow Stronger As Your Brain Grows Older by Elkhonon Goldberg.

  • BSP 28: Interview with Dr. Norman Doidge, author of The Brain That Changes Itself.

  • BSP 33: Interview with Dr. John Ratey, author of Spark: The Revolutionary New Science of Exercise and the Brain.

  • BSP 54: Interview with Dr. Michael Merzenich, author of Soft-wired.

  • BSP 87: Interview with Dr. Pam Greenwood, co-author of Nurturing the Older Brain and Mind.

Further Reading:

2013 Neuroscience Highlights (BSP 104)

Ginger Campbell with Rusty and Greta

Ginger Campbell with Rusty and Greta

Its time for the Brain Science Podcast's seventh annual review episode. In 2013 we had the chance to talk with ten scientists, including three returning guests. We also celebrated our 100th episode and passed 5 million downloads.

BSP 104 is a review of some of the key ideas we explored in 2013. I also announced the launch of a new Premium Subscription program. Beginning around December 30 the twenty-five most recent episodes will remain free while the rest of the 100+ podcasts and transcripts will be available either by subscription or for individual purchase. 

Click here to learn more about our new Premium Content.

How to get this episode:

  • FREE: audio mp3 (click to stream, right click to download)
  • Buy Transcript for $1.
  • Premium Subscribers now have unlimited access to all old episodes and transcripts.
  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

2013 Episodes and Books

Announcements

Send feedback to Dr. Campbell at brainsciencepodcast@gmail.com.

Connectome Update (BSP 103)

Olaf Sporns, PhD

Olaf Sporns, PhD

The Human Connectome is a description of the structural connectivity of the human brain, but according to Olaf Sporns, author of Discovering the Human Connectome, this description  must include a description of the brain's dynamic behavior. I first talked with Sporns back in BSP 74, but BSP 103 gave us a chance to talk about recent progress in connectomics.

Sporns sees the study of the brain's connections as fundamental to understanding how the brain works.

"It will allow us to ask new questions that perhaps we couldn’t ask before. It will be a foundational data set for us, just like the genome is. We will not be able to imagine neuroscience going back to a time when we did not have the connectome, but it will not give us all the answers.”

In his first book, Networks of the Brain, Sporns described how Network Theory provides important tools for dealing with the large data sets that are created by studying complex systems like the human brain.  In BSP 103 we discuss both the challenges and the promise of Discovering the Human Connectome

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Dangers of Diagnostic Inflation (BSP 102)

Allen Frances, MD

Allen Frances, MD

Americans are spending billions of dollars on psychiatric medications, but according to Dr. Allen Frances (Saving Normal: An Insider's Revolt Against Out-of-Control Psychiatric Diagnosis, DSM-5, Big Pharma, and the Medicalization of Ordinary Life) "We are ignoring the people who have severe psychiatric illness; so that, one-third of people with severe depression see a mental health clinician, two-thirds don't.  Two-thirds of people with severe depression get no treatment at all.  At the same time, we're way over-diagnosing people who have milder problems that would get better on their own."

Meanwhile, the drug companies push the prescribing of expensive new medications, while at least a million Americans are receiving their mental health care via the prison system. Allen argues "It shouldn't be that we deliver our psychiatric services to patients after we make them prisoners.  We should be getting the kind of community care and housing that's common in the rest of the world.  We're barbaric; we've gone back two hundred years, imprisoning psychiatric patients."

In BSP 102 Dr. Frances and I talk about the various factors that are driving these disturbing trends, including the over prescribing of psychotropic medications to young people without regard to the long term consequences. These are issues that concern us all, so I encourage you to listen to this interview and check out the additional references I have included below.

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